Arthritis is a condition that causes inflammation and pain in the joints. It can also contribute to the development of tarsal tunnel syndrome. A study published in the American Journal of Sports Medicine found that 29% of patients with tarsal tunnel syndrome had rheumatoid arthritis and 12% had osteoarthritis.

Diabetes is a chronic condition characterized by high blood sugar levels. It can cause nerve damage, which is known as diabetic neuropathy. A study published in the Journal of the American Podiatric Medical Association found that 30% of patients with tarsal tunnel syndrome had diabetes. This is because high blood sugar levels can damage the nerves that run through the tarsal tunnel, leading to compression.

Pregnancy can also contribute to the development of tarsal tunnel syndrome. A study published in the Journal of Foot and Ankle Surgery found that 14% of pregnant women who complained of foot and ankle pain had tarsal tunnel syndrome. This is because the weight gain during pregnancy can put pressure on the tibial nerve in the tarsal tunnel, leading to compression. Pregnancy can also induce carpal tunnel syndrome, the ‘sister-syndrome’.

Masses or growths such as tumors, ganglion cysts, or enlarged blood vessels can cause compression of the tibial nerve or its branches, leading to tarsal tunnel syndrome. This compression can cause irritation, inflammation, and swelling of the nerve, resulting in pain, numbness, and tingling in the foot. The pressure from the mass or growth can also impede blood flow and lead to further nerve damage. In some cases, surgical removal of the mass or growth may be necessary to alleviate the symptoms of tarsal tunnel syndrome.