Berberine & Its Effect On Living Longer
Posted on Jun 03, 2023

Berberine is a natural compound that has been used for centuries, if not longer, in traditional Chinese medicine. It is extracted from the roots, rhizomes, and stems of various plants, including the Berberis shrub, which is native to China, India, and Nepal. Berberine has been studied for its potential to improve various health conditions, including diabetes, cholesterol levels, and gastrointestinal disorders. In recent years, researchers have also looked at its potential to increase lifespan and promote healthy aging.

The Health Benefits of Berberine

Studies have shown that Berberine has numerous health benefits, including its ability to reduce inflammation, lower blood sugar levels, and improve cholesterol levels. These properties have been linked to improved cardiovascular health and a reduced risk of chronic diseases such as diabetes and heart disease. Additionally, Berberine has been found to have antibacterial, antifungal, and antioxidant properties.


Research has also suggested that Berberine may have a positive impact on lifespan. In one study, researchers investigated the effect of Berberine on the lifespan of flies. The study found that Berberine increased the lifespan of female fruit flies by up to 25%. The researchers noted that this effect was likely due to Berberine's ability to activate a protein called AMP-activated protein kinase (AMPK), which has been linked to increased lifespan and improved metabolic health in various animal models. This is a fundamental energy-sensing molecule that has the ability to dramatically alter cellular functions.


Berberine has been shown to help protect against Alzheimer’s disease. Studies suggest that berberine may be beneficial to Alzheimer’s disease by limiting the pathogenesis of extracellular amyloid plaques and intracellular neurofibrillary tangles which are known to be hallmarks of Alzheimer’s disease. Berberine also helps to regulate blood glucose levels, and hyperglycemia with its associated inflammation, is thought to be strongly involved in the pathogenesis of neurodegenerative conditions.


Studies of Berberine show that this natural supplement has anticancer effects on a variety of cancers, such as breast, lung, liver, colorectal, ovarian, and more. The reason is because it inhibits rapid cancer cell reproduction, suppresses the development of secondary malignant growths, inducing the death of cells, activates autophagy, regulates gut microbiota, and improves the effects of anticancer drugs. (Berberine is not meant to replace prescribed cancer treatments.)

Oxidative Stress

It has been reported that after treatment with Berberine, the levels of the oxidative stress-related markers decreased while the levels of internal antioxidants increased in the tissues of laboratory animals.

Living Longer with Berberine

Berberine is a natural compound with numerous health benefits, including its potential to increase lifespan and promote healthy aging. Berberine's health benefits make it a promising supplement for promoting healthy aging and wellness. Additionally, Berberine has been found to have very few side effects, making it a safe option for most people. For more information on Berberine, we have a complete guide on everything you need to know about berberine.

This supplement has been shown to lower glucose levels in people with diabetes. The body responds better to insulin and prevents the liver from creating more glucose.

This supplement has been shown to help control insulin and other hormones that regulate fat cells that can result in significant weight loss.