The Health Benefits Of Luteolin
Posted on May 13, 2021

We included Luteolin in our new Nervous System Multi for its array of health benefits.

Among the family of flavonoids, luteolin has a wide range of activities. Flavonoids are neuroprotective and anti-inflammatory.

They are antioxidant and are critical to control oxidative stress in the mitochondria and cells of the central and peripheral nervous systems.

Most flavonoids are considered to be antioxidants. The hydrogen atom from a hydroxyl group can be donated to free radicals for their neutralization. Luteolin is an aromatic compound and can support unpaired electrons.

Luteolin also is able to suppress ROS-forming oxidases. One example is the suppression of xanthine oxidase by luteolin and therefore fewer ROS in a cell.

Luteolin inhibits NF-kB signalling, TLR4 signaling and cytokine expression in mast cells. It reduces toxicity in neurons. It is able to inhibit ROS-induced damage of DNA, proteins and lipids in cells.


Luteolin regulates production of pro-inflammatory cytokines.

Luteolin has been used for the treatment of MS because of this and because it inhibits activated peripheral blood leukocytes isolated from MS patients.

Luteolin with quercetin was found to improve adaptive functioning of children with ASD.

Treatment with luteolin can decrease secondary brain injury of TBI as well.


Luteolin is thought to work very well with PEA to fight neuroinflammation and oxidative stress.

This coadministration has a superior effect than use of the molecules alone.

PEA and luteolin significantly decrease the neuroinflammation and apoptosis pathways. They modulate cytokine release and activation of astrocytes and glial cells, which decreases oxidative stress. PEA and luteolin enhance expression of neurotrophic factors and enhance regeneration of neurons.

Those that have suffered a stroke that were treated with co-PEA/Luteolin also had gains in cognitive function, muscle spasticity improvement and mobility.


Luteolin is able to cross the blood-brain barrier as well. Luteolin is involved in redox regulation, control of DNA damage and regulation of protein kinases and is used for cancer cell control; it has anticancer properties.

Luteolin suppresses the production of pro-inflammatory cytokines such as IL-6 and TNF-alpha.

This, in turn, suppresses the activation of the NF-kB and MAPK (mitogen-activated protein kinase) pathways of inducing chronic inflammation.

Luteolin effectively suppresses inflammation of brain tissues and regulates the cell signaling pathways to the benefit of the cells.

This is just one of the ingredients found in our Nervous System Multi!

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