How Does PEA Reduce Inflammation? 
Posted on Sep 09, 2020

Inflammation is a necessary part of life - and not always a bad thing. Without inflammation, we would succumb to diseases like viral infection, bacterial infections, or similar. Without inflammation, we would not be able to heal after injury.

However, too much of an inflammatory response that lasts too long is detrimental to our bodies and minds. Chronic, recurring inflammation is the likely source of all lifestyle diseases, cancers, aging, and most other afflictions that can be sparked or worsened by an inappropriate inflammatory response. To be able to control chronic inflammation is to be able to age optimally and with vitality and health. To control chronic inflammation is to have the chance to be fully happy and healthy without suffering from pain and all its limitations.


Resolution of inflammation after injury or infection is vital to the prevention of chronic inflammation. Once you enter into chronic inflammation problems develop. Anti-inflammatories as we think of them simply suppress inflammation.

What would be truly great is to convert the damaging inflammatory process into the healthy building processes of repair and remodeling. This is the goal of our product development at Well Theory; we seek to optimize wellness, healing, and thus aging. What started here at The Healing Sole has continued with Well Theory - natural, individual-led healing. Both here at The Healing Sole and in Well Theory, we believe in harnessing the body’s natural ability to heal and give you the tools to empower you on your own wellness journey.

Read more here about how you can natural relieve foot pain, including plantar fasciitis pain.


Resolution of acute inflammation involves the end of production of proinflammatory cytokines and stopping the influx of neutrophils to the inflamed site.

Macrophages that began by assisting neutrophils in the demolition of infected or damaged tissues change into macrophages that produce pro-healing molecules and pro-resolution chemicals. The macrophages will eventually leave the site altogether.

During this process, tissue healing and tissue repair occurs and the destruction, swelling, heat, and pain associated with acute inflammation should end as healing progresses. Your experience may be different - the timing of your body’s inflammatory processes depends on the abilities of your innate and adaptive immune system.


Immune signaling and function are extremely important for inflammation and the resolution of inflammation. There are a variety of cells involved to include monocytes and macrophages. Immune cells have receptors on the lipid bilayer walls and also within the cells themselves that respond to inflammation, cytokines, and other cellular messengers. These receptors are what cause pro-healing and resolution of acute inflammation.


PEA (palmitoylethanolamide) is a fatty acid amide molecule involved in the processes surrounding chronic inflammation and pain. Research has shown that PEA acts strongly on some of the receptors responsible for reducing inflammation. One of these is called PPAR-lambda (peroxisome proliferator-activated receptors). PPARs are extremely important for the conversion of macrophages from being pro-inflammatory (M1) to being pro-healing (M2).

Some pharmaceutical drugs target PPARs and treat conditions like diabetes (thiazolidinediones). Diabetes is a lifestyle disease usually and is, at its core, due to chronic inflammation. Natural substances such as DHA/EPA (Omega-3s) also target PPARs to reduce inflammation.

Read More: The Basics of PEA

These omega-3-polyunsaturated fatty acids belong to a group known as ‘specialized pro-resolving mediators’ (SPMs), alongside PEA. Other synthetics like Ibuprofen or Indomethacin also play a role in the stimulation and modulation of PPARs.

SPMs, of which PEA is included, is a group of endogenously produced lipid-derived compounds that our bodies and brains use to resolve inflammation.

Essentially, PEA is one of the critical compounds your body uses to naturally resolve inflammation.Sadly, many of us are deficient in SPMs due to lifestyle, diet, and environmental toxins.

There is a biologic connection between SPMs like PEA and PPARs that could change medicine and health; this is now being studied.

Most SPMs like PEA are just metabolites of the dietary polyunsaturated fatty acids like Omega-3s, thankfully making supplementation of these critical compounds an achievable goal.

By stimulating the PPARs, the production of pro-inflammatory and damaging cytokines is reduced. PPAR stimulation enhances the macrophagic conversion to the pro-healing type. PPAR stimulation promotes better and more balanced function of the innate and adaptive immune systems.

Research has even shown that stimulation of PPARs by supplementing with fatty acids, such as Omega-3’s, supports better mitochondrial function and antioxidant activities. PPAR receptors play critical roles in all phases of inflammation to include the resolution phase. 


PEA has long been proven to act as an anti-pain and anti-inflammatory agent; it is believed to do so via the PPAR system and others of the endocannabinoid system. PEA is used for its anti-neuroinflammatory, analgesic, and neuroprotective properties throughout the world.

Our Well Theory Essential PEA multivitamin and foot cream are formulated with PEA to help you find relief from chronic pain easily. Simply incorporate our daily multivitamin into your routine to introduce pain relief and joint and tissue support, and natural anti-inflammatory properties into your day.

We include these ingredients in our Advanced Connective Tissue Support Multivitamin, in addition to PEA:

  • Magnesium Oxide & Calcium Citrate - promotes healthy bones, reduces muscle cramps, and boosts nerve signaling
  • Vitamin D3 - strengthens nerve health and helps the body to more readily absorb calcium
  • Vitamin C - supports wound healing, collagen formation, and increase the health of bones, joints, and teeth
  • Zinc Gluconate - improves wound healing and connective tissue formation

We include these ingredients in our Foot Pain Relief Cream, in addition to PEA:

  • Lidocaine - relieves nerve pain and muscle soreness quickly when applied topically
  • Menthol - interacts with pain receptors to alleviate sensitivity and cool on contact
  • A Curated Blend of Essential Oils - stimulates physical and nerve-related responses to calm irritation, reduce pain, and lessen inflammation

When paired with PEA, these ingredients offer a powerful solution to pain, tension, and improve overall wellness from the inside out.

These products work both within the body and topically to help you go throughout your day without pain and sensitivity. Pair them with your Healing Sole footwear to fight pain and improve your foot health to keep recurring foot pain at bay.

Our specialized line of Well Theory products are back in stock, so make sure to order today!