Your Essential Guide To Our Berberine
Posted on Apr 29, 2023

Dr. Meredith Warner’s new Longevity series has been curated to help you unlock the ability to slow cellular and mitochondrial aging and possibly reduce your biological age. Berberine activates AMPK (AMP-activated protein kinase). The AMPK pathway regulates cellular energy and cellular homeostasis. AMPK is one of the primary nutrient sensing enzymes in the body and is present in all mammals. Berberine has been shown to lower blood sugar, cause weight loss and improve heart health, to name a few. It does so by triggering the activity of AMPK on the mitochondria.

It is one of the few supplements shown to be as effective as a pharmaceutical drug.

Longevity Benefits of Berberine Supplementation:

  • AMPK Activation: ramps up energy consumption within mitochondria keeping cells youthful
  • It increases glucose uptake by cells out of the blood, this helps lower blood glucose levels
  • Mimics Diabetic Drug Metformin: shown to increase insulin sensitivity and lower blood glucose levels. Many studies show that berberine can significantly reduce blood sugar levels in individuals with type 2 diabetes
  • Improve Metabolic Health: improve brain function, memory, mood, energy, and risk of chronic disease AMPK decreases energy consuming activities like lipid synthesis
  • Weight Control: thought to be achievable through stimulating metabolism, lowering blood sugar, reducing appetite, and increasing energy
Berberine is a natural way to increase AMPK in much the same way that Metformin does. More and more studies found while looking at diabetics and the ones that were on Metformin did better in every parameter. They had less cancer, less heart disease, lived longer, had less arthritis, had less pain, and generally felt better. Berberine has been found to be as good as if not better than Metformin.
- Orthopedic Surgeon, Dr. Meredith Warner, Founder of Well Theory


Q: I’ve heard Metformin is bad. What about Berberine?

A: While Metformin is typically highly recommended, especially for those with diabetes, it can cause gastrointestinal issues that may leave some people uncomfortable. That’s another reason that supplementing with Berberine is a great alternative to Metformin.

Berberine can be as effective as Metformin, but in a more gentle manner, which makes it beneficial for those who have side effects from taking Metformin. It’s also great for those who don’t have diabetes, but want to improve their overall metabolic health, maintain their weight and combat aging through AMPK activation. There is currently ongoing a large study looking at the longevity-improvements associated with metformin.

As always, we recommend consulting with your treating physician prior to starting any new supplements.

Q: Can I take Berberine and Metformin at the same time?

A: Berberine and Metformin act the same way in the body when lowering blood sugar levels. It is possible for the two to act too well together and lower blood sugar too much. Some medical sources say that both can be taken together. We recommend consulting with your physician to determine if berberine is safe to take based on your medical history.


Q: Can I take Berberine forever?

A: Clinical studies focused on supplementing with Berberine have run for several weeks, up to two years. These studies indicated that Berberine was safe and beneficial under these circumstances. There isn’t any evidence that it is not safe to take long-term.

Berberine is a generally safe supplement to take, and although it mimics Metformin in effectiveness, it acts in a more gentle manner.

Of course, we always recommend consulting with your treating physician prior to adding any new supplements to your routine.

Q: Does Berberine Improve Metabolism?

A: Yes! Metabolic health is defined by 5 markers: blood sugar, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure, and waist circumference. Berberine affects all 5 markers!

Q: What is insulin resistance and why should I worry about it?

A: Insulin resistance happens when the cells in your body don’t respond properly to insulin. Lowered insulin sensitivity if left unchecked can result in higher blood glucose levels that can develop into prediabetes and type-2 diabetes.

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